An Unbiased View of PP88
An Unbiased View of PP88
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23. A nucleic acid vector to be used in in vivo supply of a nucleic acid of fascination right into a targeted receiver bacterial cell, mentioned nucleic acid of fascination making a presented effect on mentioned specific receiver bacterial mobile, wherein explained vector comprises: mentioned nucleic acid of interest, and
262、细菌噬菌体可选自长尾噬菌体科(非限制性地比如以下属：cam病毒、lika病毒、r4病毒、acadian病毒、cooper病毒、pg1病毒、pipefish病毒、rosebush病毒、brujita病毒、che9c病毒、hawkeye病毒、plot病毒、jersey病毒、k1g病毒、sp31病毒、lmd1病毒、una4病毒、bongo病毒、rey病毒、butters病毒、charlie病毒、redi病毒、baxter病毒、nymphadora病毒、bignuz病毒、fishburne病毒、phayonce病毒、kp36病毒、rogue1病毒、rtp病毒、t1病毒、tls病毒、ab18病毒、amigo病毒、anatole病毒、andromeda病毒、attis病毒、barnyard病毒、bernal13病毒、biseptima病毒、bron病毒、c2病毒、c5病毒、cba181病毒、cbast病毒、ceci病毒、che8病毒、chi病毒、cjw1病毒、corndog病毒、cronus病毒、d3112病毒、d3病毒、decurro病毒、demosthenes病毒、doucette病毒、e125病毒、eiau病毒、ff47病毒、gaia病毒、giles病毒、gordon病毒、gordtnk病毒、harrison病毒、hk578病毒、hk97病毒、jenst病毒、jwx病毒、kellezio病毒、korra病毒、l5病毒、lambda病毒、laroye病毒、liefie病毒、marvin病毒、mudcat病毒、n15病毒、nonag病毒、np1病毒、omega病毒、p12002病毒、p12024病毒、p23病毒、p70病毒、pa6病毒、pamx74病毒、patience病毒、pbi1病毒、pepy6病毒、pfr1病毒、phic31病毒、phicbk病毒、phieta病毒、phifel病毒、phijl1病毒、pis4a病毒、psa病毒、psimuna病毒、rdjl病毒、rer2病毒、sap6病毒、send513病毒、septima3病毒、seurat病毒、sextaec病毒、sfi11病毒、sfi21dt1病毒、sitara病毒、sk1病毒、slash病毒、smoothie病毒、soups病毒、spbeta病毒、ssp2病毒、t5病毒、tank病毒、tin2病毒、titan病毒、tm4病毒、tp21病毒、tp84病毒、tria病毒、trigintaduo病毒、vegas病毒、vendetta病毒、wbeta病毒、wildcat病毒、wizard病毒、woes病毒、xp10病毒、ydn12病毒和yua病毒)。
In a particular embodiment, claimed supplied impact is to selectively remove antibiotic resistance from antibiotic resistant bacterial strains.
ten. the strategy according to any one of embodiments one to four, whereby claimed supplied result is earning the receiver bacterial mobile stop producing a supplied molecule and whereby stated specified molecule is selected from your team consisting of the toxin, a harmful aspect, a virulence protein, a virulence factor, a protein encoded by an antibiotic resistance gene, a protein encoded by a reworking gene or by a modulatory gene.
stated HMM might even further have any influence. In a selected embodiment, stated HMM may be a molecule that will have an affect on the immune technique on the host, the host CNS and/or even the host metabolism.
The bacterial delivery autos are typically geared up from bacterial virus. The bacterial supply autos are generally picked out so as in order to introduce the vector in the focused germs.
In a selected embodiment, antibiotic resistant strains are targetly killed by programming the nuclease to perform a DNA cleavage, e.
In a selected embodiment, stated probiotic is just not affected via the vector from the creation. In a specific embodiment, when mentioned vector is comprised in a very bacterial supply vehicle, claimed car may bind to stated probiotic but reported probiotic will not be affected by claimed vector.
The manufacture of reported molecule of curiosity by explained focused receiver bacterial cell might demand the delivery of a nucleic acid of fascination which incorporates a number of sort(s) of gene(s) or team(s) of genes. specifically, mentioned nucleic acid of fascination may be selected from your group consisting of a gene encoding mentioned molecule of desire, specifically stated HMM, several genes encoding a protein intricate that is the molecule of curiosity, especially the HMM, a gene or team of genes encoding enzyme(s) of a metabolic pathway leading to the manufacture of the molecule of desire, in particular from the HMM, a coding nucleic acid which happens to be the molecule of interest, particularly the HMM, and a non-coding nucleic acid which is the molecule of interest, specifically the HMM.
in a few embodiments, focused receiver bacterial cells on the present disclosure are anaerobic bacterial cells (e.g., cells that do not need oxygen for growth). Anaerobic bacterial cells incorporate facultative anaerobic cells for instance but not restricted to Escherichia coli, Shewanella oneidensis and Listeria.
The packaged phagemid could possibly be made using a satellite virus tactic, also recognised within the gentleman expert during the artwork. 現在享受賭博樂趣 Satellite virus are subviral agent and so are made up of nucleic acid that depends upon the co-infection of a host mobile which has a helper virus for all the morphogenetic features, Whilst for all its episomal features (integration and immunity, multicopy plasmid replication) the satellite is completely autonomous in the helper. in a single embodiment, the satellite genes can encode proteins that endorse capsid dimension reduction of the helper phage, as explained for that P4 Sid protein that controls the P2 capsid measurement to fit its lesser genome.
These gene sequences might be modified to decrease the homology With all the human sequences and forestall cross-reactivity of People regarded because of the host immune program Along with the human counterpart.
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wherein, at the time sent into said specific receiver bacterial cell, said nucleic acid of interest provides claimed supplied effect on explained qualified receiver bacterial mobile even though mentioned vector just isn't replicated in claimed targeted receiver bacterial cell.
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